Publications

Title: EGFR amplification and PI3K pathway mutations identify a subset of breast cancers that synergistically respond to EGFR and PI3K inhibition

Authors: D. J. Wisniewski, D. Voeller, Y. A. Addissie, S. K. Deshmukh, S. Wu, M. B. Lustberg, D. Wangsa, D. Wangsa, K. Heselmeyer-Haddad, G. W. Sledge and S. Lipkowitz.

Journal: Oncogene. 2026 Jan;45(1):15-25.

Title: Genetic background and oncogenic driver determines the genomic evolution and transcriptomics of mammary tumor metastasis

Authors: C. R. Ross, K. Szczepanek, J. Sanford, G. Needle, T. Qiu, L. Pearce, M. P. Lee and K. W. Hunter.

Journal: Commun Biol. 2025 Aug 14;8(1):1224.

Title: Targeting a pathogenic cryptic exon that drives HLRCC to induce exon skipping

Authors: S. S. Maligireddy, M. D. Mandler, J. C. Lunger, M. Yuen, S. Kulkarni, A. R. Perez, C. M. Fitzsimmons, D. R. Crooks, R. Chari, W. M. Linehan and P. J. Batista.

Journal: Mol Ther Nucleic Acids. 2025 Aug 5;36(3):102668.

Title: Single-cell and spatial transcriptomics map senescent vascular cells in arterial remodeling during atherosclerosis in mice

Authors: K. Mazan-Mamczarz, D. Tsitsipatis, B. G. Childs, A. E. Carr, C. R. Dos Santos, C. Anerillas, B. Romero, J. M. Gregg, C. Henry-Smith, A. N. Okereke, M. Michel, R. Munk, J. L. Martindale, Y. Piao, J. Fan, M. O. Hernandez, N. Kedei, M. L. Viacheslavov, M., M. F. Wong, O. V. Fedorova, M. Batish, S. De, D. J. Baker, M. Gorospe and A. B. Herman.

Journal: Nat Aging. 2025 Aug;5(8):1528-1547.

Title: TGFB signaling induces mitophagy via PLSCR3-mediated cardiolipin externalization in conjunction with a BNIP3L/NIX-, BNIP3-, and FUNDC1-dependent mechanism

Authors: J. Yan, X. Chen, S. Choksi and Z. G. Liu.

Journal: Autophagy. 2025 Aug;21(8):1791-1801.

Title: Identification of a Novel Intracellular Function of the Secreted Ribonuclease RNASE1 in Inhibiting Gene Expression

Authors: R. Singh, A. Archibald, X. L. Li, R. Kumar, S. Das, E. C. Pehrsson, P. X. Zhao, X. Wen, R. Chari, I. Grammatikakis and A. Lal.

Journal: Mol Cell Biol. 2025;45(8):315-326.

Title: The Kinase Inhibitor GNF-7 Is Synthetically Lethal in Topoisomerase 1-Deficient Ewing Sarcoma

Authors: C. M. Sayers, M. B. Carter, H. Lei, A. Mendoza, S. Shema, X. Zhang, K. Wilson, L. Chen, C. Klumpp-Thomas, C. J. Thomas, C. M. Heske and J. F. Shern.

Journal: Cancers (Basel). 2025 Jul 26;17(15):2475.

Title: SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases

Authors: R. Trehan, P. Huang, X. B. Zhu, X. Wang, M. Soliman, D. Strepay, A. Nur, N. Kedei, M. Arhin, S. Ghabra, F. Rodriguez-Matos, M. R. Benmebarek, C. Ma, F. Korangy and T. F. Greten.

Journal: Nat Commun. 2025 May 7;16(1):4242.

Title: CD22 TCR-engineered T cells exert antileukemia cytotoxicity without causing inflammatory responses

Authors: K. A. Nguyen, Z. Liu, J. S. Davies, C. P. McIntosh, L. M. Draper, S. M. Norberg, Z. Rae, S. R. Achar, G. Altan-Bonnet, L. Zhang, X. Wu, T. J. Meyer, M. C. Kelly, N. Taylor, C. S. Hinrichs and K. Ishii.

Journal: Sci Adv. 2025 Apr 11;11(15):eadq4297.

Title: Liver quad culture chip as a model for radiation injury research

Authors: Y. Ueda, S. Omiya, J. Pinney, M. A. Bylicky and M. J. Aryankalayil.

Journal: Sci Rep. 2025 Apr 11;15(1):12414.

Title: Anti-vascular endothelial growth factor treatment potentiates immune checkpoint blockade through a BAFF- and IL-12-dependent reprogramming of the TME

Authors: M. R. Benmebarek, C. Oguz, M. Seifert, B. Ruf, Y. Myojin, K. C. Bauer, P. Huang, C. Ma, M. Villamor-Paya, F. Rodriguez-Matos, M. Soliman, R. Trehan, C. Monge, C. Xie, D. E. Kleiner, B. J. Wood, E. B. Levy, A. Budhu, N. Kedei, C. T. Mayer, X. W. Wang, J. Lack, W. Telford, F. Korangy and T. F. Greten

Journal: Immunity. 2025 Apr 8;58(4):926-945.e10.

Title: Mechanism for local attenuation of DNA replication at double-strand breaks

Authors: R. Sebastian, E. G. Sun, M. Fedkenheuer, H. Fu, S. Jung, B. L. Thakur, C. E. Redon, G. Pegoraro, A. D. Tran, J. M. Gross, S. Mosavarpour, N. A. Kusi, A. Ray, A. Dhall, L. S. Pongor, R. Casellas and M. I. Aladjem.

Journal: Nature. 2025 Mar;639(8056):1084-1092.

Title: Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition

Authors: H. Li, T. Furusawa, R. Cavero, Y. Xiao, R. Chari, X. Wu, D. Sun, O. Hartmann, A. Dhall, R. Holewinski, T. Andresson, B. Karim, M. Villamor-Payà, D. Gallardo, C.-P. Day, L. R. Pal, N. U. Nair, E. Ruppin, M. I. Aladjem, Y. Pommier, M. E. Diefenbacher, J. M. Lim, R. L. Levine, T. H. Stracker and U. Weyemi

Journal: Redox Biol. 2025 Mar:80:103503.

Title: A KIF1C-CNBP motor-adaptor complex for trafficking mRNAs to cell protrusions

Authors: K. Moissoglu, T. Wang, A. N. Gasparski, M. Stueland, E. L. Paine, L. Jenkins and S. Mili.

Journal: Cell Rep. 2025 Mar 25;44(3):115346.

Title: A convenient single-cell newly synthesized transcriptome assay reveals FLI1 downregulation during T-cell activation

Authors: J. Lyu, X. Xu and C. Chen

Journal: bioRxiv[Preprint]. 2025 Mar 13:2024.08.22.609222.

Title: Mutations in the Staphylococcus aureus Global Regulator CodY confer tolerance to an interspecies redox-active antimicrobial

Authors: A. M. Martini, S. A. Alexander and A. Khare.

Journal: PLoS Genet. 2025 Mar 7;21(3):e1011610.

Title: Temporal mapping of the anti-tumor effects of nanobody-based MSLN.CAR-T cell therapy in metastatic solid tumors

Authors: C. Stathopoulou, M. Zhao, Q. Jiang, J. Hong, J. Bian, J. Zhang, M. Ho and R. Hassan.

Journal: bioRxiv[Preprint]. 2025 Mar 2:2025.02.26.640438.

Title: Neoadjuvant intratumoral MBT(A) immunotherapy prevents distant metastases and recurrence in murine models

Authors: O. Uher, K. H. Vanova, R. Labitt, K. Petrlakova, J. Ye, H. Wang, M. Masarik, M. Jakubek, J. Zenka, Z. Zhuang and K. Pacak.

Journal: Cancer Lett. 2025 Mar 1:612:217464.

Title: CRISPR screening identifies regulators of enhancer-mediated androgen receptor transcription in advanced prostate cancer

Authors: R. R. Xiang, S. A. Lee, C. F. Tyndall, A. R. Bhatia, J. Yin, C. Singler, B. J. Hauk, M. P. Kipp and D. Y. Takeda.

Journal: Cell Rep. 2025 Feb 25;44(2):115312.

Title: Direct ionic stress sensing and mitigation by the transcription factor NFAT5

Authors: C. B. Khandwala, P. Sarkar, H. B. Schmidt, M. Ma, G. V. Pusapati, F. Lamoliatte, M. Kinnebrew, B. B. Patel, D. Tillo, A. M. Lebensohn and R. Rohatgi.

Journal: Sci Adv. 2025 Feb 21;11(8):eadu3194.

Title: Pericyte-tumor crosstalk facilitates metastatic tumor cell latency through PIEZO1-activated lysophospholipid transfer

Authors: T. McErlain, M. J. Glass, E. C. McCulla, C. A. Madden, L. E. Ziemer, K. E. Overdahl, A. K. Jarmusch, M. J. Kruhlak, A. T. Chesler, H. H. Yang, M. P. Lee, C. M. Branco and M. Murgai.

Journal: bioRxiv[Preprint]. 2025 Feb 17:2025.02.15.638347.

Title: Plasma Cell-Free DNA Chromatin Immunoprecipitation Profiling Depicts Phenotypic and Clinical Heterogeneity in Advanced Prostate Cancer

Authors: J. Sipola, A. D. Munzur, E. M. Kwan, C. C. Y. Seo, B. J. Hauk, K. Parekh, Y. J. R. Liao, C. Q. Bernales, G. Donnellan, I. Bloise, E. Fung, S. W. S. Ng, G. Wang, G. Vandekerkhove, M. Nykter, M. Annala, C. Maurice-Dror, K. N. Chi, C. Herberts, A. W. Wyatt and D. Y. Takeda.

Journal: Cancer Res. 2025 Feb 17;85(4):791-807.

Title: ASAP1 and ARF1 Regulate Myogenic Differentiation in Rhabdomyosarcoma by Modulating TAZ Activity

Authors: K. E. Hebron, O. L. Perkins, A. Kim, X. Jian, S. A. Girald-Berlingeri, H. Lei, J. F. Shern, E. A. Conner, P. A. Randazzo and M. E. Yohe.

Journal: Mol Cancer Res. 2025 Feb 6;23(2):95-106.

Title: Hsp90, DnaK, and ClpB collaborate in protein reactivation

Authors: J. R. Hoskins, A. C. Wickramaratne, C. P. Jewell, L. M. Jenkins and S. Wickner.

Journal: Proc Natl Acad Sci U S A. 2025 Feb 4;122(5):e2422640122.

Title: TRα1 mutant suppresses KLF9 to cause endometrial metaplasia with ectopic IL-33 expression leading to uterine fibrosis and infertility

Authors: E. Edmondson, T. Kimura, E. Hwang, M. Kim, A. Warner, Y. Zhu, L. Zhao, Y. Yu, X. Zhu, M. Hernandez, N. Kedei and S. Y. Cheng.

Journal: Sci Rep. 2025 Jan 31;15(1):3892.

Title: Investigating the genomic landscape of mouse models of breast cancer metastasis

Authors: C. R. Ross, K. Szczepanek, J. Sanford, T. Qiu, L. Pearce and K. W. Hunter.

Journal: bioRxiv[Preprint]. 2025 Jan 19:2025.01.15.633216.

Title: Role of B cells in intratumoral MBTA immunotherapy of murine pheochromocytoma model

Authors: O. Uher, K. Hadrava Vanova, K. Petrlakova, R. Labitt, R. Lencova, A. Frejlachova, J. Ye, H. Wang, M. Masarik, J. Zenka, Z. Zhuang and K. Pacak.

Journal: Best Pract Res Clin Endocrinol Metab. 2025 Jan;39(1):101941.

Title: Topoisomerase-modulated genome-wide DNA supercoiling domains colocalize with nuclear compartments and regulate human gene expression

Authors: Q. Yao, L. Zhu, Z. Shi, S. Banerjee and C. Chen.

Journal: Nat Struct Mol Biol. 2025 Jan;32(1):48-61.

Title: Head and neck paraganglioma in Pacak-Zhuang syndrome

Authors: J. S. Rosenblum, Y. Cole, D. Dang, P. P. Lookian, H. Alkaissi, M. Patel, A. J. Cappadona, A. Jha, N. Edwards, D. R. Donahue, J. Munasinghe, H. Wang, R. H. Knutsen, A. S. Pappo, R. M. Lechan, B. A. Kozel, J. G. Smirniotopoulos, H. J. Kim, A. Vortmeyer, M. Miettinen, J. D. Heiss, Z. Zhuang and K. Pacak.

Journal: JNCI Cancer Spectr. 2025 Jan 3;9(1):pkaf001.

Title: Estimating and correcting index hopping misassignments in single-cell RNA-seq data

Authors: L. Miao, L. Collado, S. Barkdull, Y. Saito, J.-H. Jo, J. Han, S. Dell’Orso, M. C. Kelly, S. Conlan, H. H. Kong and I. Brownell.

Journal: bioRxiv[Preprint]. 2024 Dec 16:2024.10.21.619353.

Title: Non-coding genetic variants underlying higher prostate cancer risk in men of African ancestry

Authors: S. Li, K. Fatema, S. Nidharshan, A. Singh, P. S. Rajagopal, D. Notani, D. Y. Takeda and S. Hannenhalli.

Journal: Res Sq [Preprint]. 2024 Dec 5:rs.3.rs-5485172.

Title: Multiomics Profiling Distinguishes Sebaceous Carcinoma from Benign Sebaceous Neoplasms and Provides Insight into the Genetic Evolution of Sebaceous Carcinogenesis

Authors: G. J. Starrett, B. C. Baikie, B. K. Stoff, H. E. Grossniklaus, I. Van Buren, E. G. Berry, R. A. Novoa, K. E. Rieger, K. Y. Sarin, C. F. Lynch, M. C. Royer, M. L. Piaskowski, I. Brownell, E. Y. Chu, R. Godse, S. C. Chen, K. J. Yu, A. M. Goldstein, E. A. Engels and M. R. Sargen

Journal: Clin Cancer Res. 2024 Nov 1;30(21):4887-4899.

Title: Targeting SWI/SNF ATPases reduces neuroblastoma cell plasticity

Authors: Xu, M., Hong, J. J., Zhang, X., Sun, M., Liu, X., Kang, J., Stack, H., Fang, W., Lei, H., Lacoste, X., Okada, R., Jung, R., Nguyen, R., Shern, J. F., Thiele, C. J., & Liu, Z.

Journal: EMBO J. 2024 Oct;43(20):4522-4541.

Title: Interspecies surfactants serve as public goods enabling surface motility in Pseudomonas aeruginosa

Authors: D. L. Warrell, T. M. Zarrella, C. Machalek and A. Khare.

Journal: J Bacteriol. 2024 Oct 24;206(10):e0028124.

Title: Treatment with novel topoisomerase inhibitors in Ewing sarcoma models reveals heterogeneity of tumor response

Authors: U. Lee, L. Szabova, V. J. Collins, M. Gordon, K. Johnson, D. Householder, S. Jorgensen, L. Lu, L. Bassel, F. Elloumi, C. J. Peer, A. E. Nelson, S. Varriano, S. Varma, R. D. Roberts, Z. W. Ohler, W. D. Figg, S. K. Sharan, Y. Pommier and C. M. Heske.

Journal: Front Cell Dev Biol. 2024 Oct 24:12:1462840.

Title: A novel pathogenic germline chromosome 3 inversion in von Hippel-Lindau disease

Authors: C. D. Vocke, C. J. Ricketts, S. Pack, M. Raffeld, S. Hewitt, A. P. Lebensohn, L. O’Brien, R. Gautam, K. Reynolds, L. S. Schmidt, K. Choo, A. Kenigsberg, S. Gurram, E. Y. Chew, N. Nilubol, P. Chittaboina, M. J. Merino, M. W. Ball and W. M. Linehan

Journal: J Med Genet. 2024 Oct 23;61(11):1026-1030.

Title: Bacterial spore surface nanoenvironment requires a AAA+ ATPase to promote MurG function

Authors: T. Delerue, T. B. Updegrove, S. Chareyre, V. Anantharaman, M. C. Gilmore, L. M. Jenkins, D. L. Popham, F. Cava, L. Aravind and K. S. Ramamurthi

Journal: Proc Natl Acad Sci U S A. 2024 Oct 22;121(43):e2414737121.

Title: Altruistic feeding and cell-cell signaling during bacterial differentiation actively enhance phenotypic heterogeneity

Authors: T. B. Updegrove, T. Delerue, V. Anantharaman, H. Cho, C. Chan, T. Nipper, H. Choo-Wosoba, L. M. Jenkins, L. Zhang, Y. Su, H. Shroff, J. Chen, C. A. Bewley, L. Aravind and K. S. Ramamurthi.

Journal: Sci Adv. 2024 Oct 18;10(42):eadq0791.

Title: CAR-T cells based on a TCR mimic nanobody targeting HPV16 E6 exhibit antitumor activity against cervical cancer

Authors: Z. Duan, D. Li, N. Li, S. Lin, H. Ren, J. Hong, C. S. Hinrichs and M. Ho.

Journal: Mol Ther Oncol. 2024 Oct 9;32(4):200892.

Title: Staufen1 Represses the FOXA1-Regulated Transcriptome by Destabilizing FOXA1 mRNA in Colorectal Cancer Cells

Authors: K. R. Pasterczyk, X. L. Li, R. Singh, M. S. Zibitt, C. C. R. Hartford, L. Pongor, L. M. Jenkins, Y. Hu, P. X. Zhao, B. R. Muys, S. Kumar, N. Roper, M. I. Aladjem, Y. Pommier, I. Grammatikakis and A. Lal.

Journal: Mol Cell Biol. 2024;44(2):43-56.

Title: Structure and repair of replication-coupled DNA breaks

Authors: Pavani R, Tripathi V, Vrtis KB, Zong D, Chari R, Callen E, Pankajam AV, Zhen G, Matos-Rodrigues G, Yang J, Wu S, Reginato G, Wu W, Cejka P, Walter JC, Nussenzweig A.

Journal: Science. 2024 Aug 16;385(6710):eado3867.

Title: Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4

Authors: M. Mizunuma, C. E. Redon, L. K. Saha, A. D. Tran, A. Dhall, R. Sebastian, D. Taniyama, M. J. Kruhlak, W. C. Reinhold, N. Takebe and Y. Pommier.

Journal: Cancer Res Commun. 2024 Aug 1;4(8):2101-2111.

Title: The DNA Methyltransferase Inhibitor 5-Aza-4'-thio-2'-Deoxycytidine Induces C>G Transversions and Acute Lymphoid Leukemia Development

Authors: R. M. Bertoli, Y. J. Chung, M. J. Difilippantonio, A. Wokasch, M. R. B. Marasco, H. Klimaszewski, S. Gammell, Y. J. Zhu, R. L. Walker, D. Cao, A. Khanna, M. J. Walter, J. H. Doroshow, P. S. Meltzer and P. D. Aplan

Journal: Cancer Res. 2024 Aug 1;84(15):2518-2532.

Title: The modification landscape of Pseudomonas aeruginosa tRNAs

Authors: Mandler, M. D., Maligireddy, S. S., Guiblet, W. M., Fitzsimmons, C. M., McDonald, K. S., Warrell, D. L., & Batista, P. J.

Journal: RNA. 2024 Jul 16;30(8):1025-1040

Title: Tongue orthotopic xenografts to study fusion-negative rhabdomyosarcoma invasion and metastasis in live animals

Authors: S. M. Hammoudeh, Y. Ng, B. R. Wei, T. D. Madsen, M. P. Yadav, R. M. Simpson, R. Weigert and P. A. Randazzo

Journal: Cell Rep Methods. 2024 Jul 15;4(7):100802.

Title: Stem cell dynamics and cellular heterogeneity across lineage subtypes of castrate-resistant prostate cancer

Authors: M. L. Beshiri, B. J. Capaldo, R. Lake, A. T. Ku, D. Burner, C. M. Tice, C. Tran, J. Kostas, A. N. Alilin, J. Yin, S. Agarwal, S. A. Morris, F. H. Karzai, T. L. Lotan, W. L. Dahut, A. G. Sowalsky and K. Kelly

Journal: Stem Cells. 2024 Jun 14;42(6):526-539.

Title: Real-time visualization of spliceosome assembly reveals basic principles of splice site selection

Authors: B. T. Donovan, B. Wang, G. R. Garcia, S. M. Mount and D. R. Larson.

Journal: bioRxiv[Preprint]. 2024 Jul 13:2024.07.12.603320.

Title: Enhanced ac4C detection in RNA via chemical reduction and cDNA synthesis with modified dNTPs

Authors: Relier S, Schiffers S, Beiki H, Oberdoerffer S.

Journal: RNA. 2024 Jun 17;30(7):938-953.

Title: Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

Authors: Desai P, Takahashi N, Kumar R, Nichols S, Malin J, Hunt A, Schultz C, Cao Y, Tillo D, Nousome D, Chauhan L, Sciuto L, Jordan K, Rajapakse V, Tandon M, Lissa D, Zhang Y, Kumar S, Pongor L, Singh A, Schroder B, Sharma AK, Chang T, Vilimas R, Pinkiert D, Graham C, Butcher D, Warner A, Sebastian R, Mahon M, Baker K, Cheng J, Berger A, Lake R, Abel M, Krishnamurthy M, Chrisafis G, Fitzgerald P, Nirula M, Goyal S, Atkinson D, Bateman NW, Abulez T, Nair G, Apolo A, Guha U, Karim B, El Meskini R, Ohler ZW, Jolly MK, Schaffer A, Ruppin E, Kleiner D, Miettinen M, Brown GT, Hewitt S, Conrads T, Thomas A.

Journal: Cell Rep Med. 2024 Jun 18;5(6):101610.

Title: DRD1 suppresses cell proliferation and reduces EGFR activation and PD-L1 expression in NSCLC

Authors: C. E. Grant, A. L. Flis, L. Toulabi, A. Zingone, E. Rossi, K. Aploks, H. Sheppard and B. M. Ryan.

Journal: Mol Oncol. 2024 Jun;18(6):1631-1648.

Title: DNAJC9 prevents CENP-A mislocalization and chromosomal instability by maintaining the fidelity of histone supply chains

Authors: V. Balachandra, R. L. Shrestha, C. M. Hammond, S. Lin, I. A. Hendriks, S. C. Sethi, L. Chen, S. Sevilla, N. J. Caplen, R. Chari, T. S. Karpova, K. McKinnon, M. A. Todd, V. Koparde, K. C. Cheng, M. L. Nielsen, A. Groth and M. A. Basrai.

Journal: EMBO J. 2024 Jun;43(11):2166-2197.

Title: Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate

Authors: J. Zhan, A. Zeher, R. Huang, W. K. Tang, L. M. Jenkins and D. Xia.

Journal: Nat Commun. 2024 May 31;15(1):4655.

Title: The homeobox transcription factor DUXBL controls exit from totipotency

Authors: Vega-Sendino, M., Lüttmann, F. F., Olbrich, T., Chen, Y., Kuenne, C., Stein, P., Tillo, D., Carey, G. I., Zhong, J., Savy, V., Radonova, L., Lu, T., Saykali, B., Kim, K. P., Domingo, C. N., Schüler, L., Günther, S., Bentsen, M., Bosnakovski, D., Schöler, H., Ruiz, S.

Journal: Nat Genet. 2024 Apr;56(4):697-709.

Title: Establishment and Characterization of Amitrole-Induced Mouse Thyroid Adenomatous Nodule-Derived Cell Lines

Authors: Y. T. Shirai, N. Hoshi, J. M. Ward, H. Liu, R. E. Cachau, M. P. Lee, S. Kimura.

Journal: Thyroid. 2024 Apr;34(4):496-509.

Title: Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity

Authors: E. M. Rosenberg, Jr., X. Jian, O. Soubias, R. A. Jackson, E. Gladu, E. Andersen, L. Esser, A. J. Sodt, D. Xia, R. A. Byrd and P. A. Randazzo.

Journal: PLoS One. 2024 Apr 4;19(4):e0295103.

Title: The Methyltransferases METTL7A and METTL7B Confer Resistance to Thiol-Based Histone Deacetylase Inhibitors

Authors: Robey, R. W., Fitzsimmons, C. M., Guiblet, W. M., Frye, W. J. E., González Dalmasy, J. M., Wang, L., Russell, D. A., Huff, L. M., Perciaccante, A. J., Ali-Rahmani, F., Lipsey, C. C., Wade, H. M., Mitchell, A. V., Maligireddy, S. S., Terrero, D., Butcher, D., Edmondson, E. F., Jenkins, L. M., Nikitina, T., Zhurkin, V. B., Batista, P. J.

Journal: Mol Cancer Ther. 2024 Apr 2;23(4):464-477.

Title: The recurrent deep intronic pseudoexon-inducing variant COL6A1 c.930+189C>T results in a consistently severe phenotype of COL6-related dystrophy: Towards clinical trial readiness for splice-modulating therapy

Authors: A. R. Foley, V. Bolduc, F. Guirguis, S. Donkervoort, Y. Hu, R. Orbach, R. M. McCarty, A. Sarathy, G. Norato, B. B. Cummings, M. Lek, A. Sarkozy, R. J. Butterfield, J. Kirschner, A. Nascimento, D. N. Benito, S. Quijano-Roy, T. Stojkovic, L. Merlini, G. Comi, M. Ryan, D. McDonald, P. Munot, G. Yoon, E. Leung, E. Finanger, M. E. Leach, J. Collins, C. Tian, P. Mohassel, S. B. Neuhaus, D. Saade, B. T. Cocanougher, M. L. Chu, M. Scavina, C. Grosmann, R. Richardson, B. D. Kossak, S. M. Gospe, Jr., V. Bhise, G. Taurina, B. Lace, M. Troncoso, M. Shohat, A. Shalata, S. H. S. Chan, M. Jokela, J. Palmio, G. Haliloglu, C. Jou, C. Gartioux, H. Solomon-Degefa, C. D. Freiburg, A. Schiavinato, H. Zhou, S. Aguti, Y. Nevo, I. Nishino, C. Jimenez-Mallebrera, S. R. Lamande, V. Allamand, F. Gualandi, A. Ferlini, D. G. MacArthur, S. D. Wilton, R. Wagener, E. Bertini, F. Muntoni, C. G. Bonnemann.

Journal: medRxiv[Preprint]. 2024 Mar 29:2024.03.29.24304673.

Title: Development of quantitative high-throughput screening assays to identify, validate, and optimize small-molecule stabilizers of misfolded β-glucocerebrosidase with therapeutic potential for Gaucher disease and Parkinson's disease

Authors: D. Williams, L. M. Glasstetter, T. T. Jong, A. Kapoor, S. Zhu, Y. Zhu, A. Gehrlein, D. J. Vocadlo, R. Jagasia, J. J. Marugan, E. Sidransky, M. J. Henderson, Y. Chen

Journal: bioRxiv[Preprint]. 2024 Mar 27:2024.03.22.586364.

Title: Endogenous EWSR1 Exists in Two Visual Modalities That Reflect Its Associations with Nucleic Acids and Concentration at Sites of Active Transcription

Authors: S. Sundara Rajan, V. J. Ebegboni, P. Pichling, K. R. Ludwig, T. L. Jones, R. Chari, A. Tran, M. J. Kruhlak, J. Loncarek, N. J. Caplen.

Journal: Mol Cell Biol. 2024 Mar 20;44(3):103-122.

Title: Macrophage mediated mesoscale brain mechanical homeostasis mechanically imaged via optical tweezers and Brillouin microscopy in vivo

Authors: W. Y. So, B. Johnson, P. B. Gordon, K. S. Bishop, H. Gong, H. A. Burr, J. R. Staunton, C. Handler, R. Sood, G. Scarcelli, K. Tanner.

Journal: bioRxiv[Preprint]. 2024 Mar 6:2023.12.27.573380.

Title: The cysteine-rich domain in CENP-A chaperone Scm3HJURP ensures centromere targeting and kinetochore integrity

Authors: H. D. Folco, H. Xiao, D. Wheeler, H. Feng, Y. Bai, S. I. S. Grewal.

Journal: Nucleic Acids Res. 2024 Feb 28;52(4):1688-1701.

Title: TP53 mutation screening for patients at risk of myeloid malignancy

Authors: D. Mukherjee, R. A. Lawal, C. D. Fitzhugh, C. S. Hourigan and L. W. Dillon.

Journal: medRxiv[Preprint]. 2024 Feb 8:2024.02.06.24302401.

Title: Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma

Authors: Fitzsimmons, C. M., Mandler, M. D., Lunger, J. C., Chan, D., Maligireddy, S. S., Schmiechen, A. C., Gamage, S. T., Link, C., Jenkins, L. M., Chan, K., Andresson, T., Crooks, D. R., Meier, J. L., Linehan, W. M., & Batista, P. J.

Journal: NAR Cancer. 2024 Feb 7;6(1):zcae004.

Title: Loss of NAT10 disrupts enhancer organization via p300 mislocalization and suppresses transcription of genes necessary for metastasis progression

Authors: R. Amin, N.-H. Ha, T. Qiu, R. Holewinski, K. C. Lam, A. Lopès, H. Liu, A. D. Tran, M. P. Lee, S. T. Gamage, T. Andresson, R. S. Goldszmid, J. L. Meier, K. W. Hunter.

Journal: bioRxiv[Preprint]. 2024 Jan 29:2024.01.24.577116.

Title: Detection of Extracellular Vesicle-Derived RNA as Potential Prostate Cancer Biomarkers: Role of Cancer-type SLCO1B3 and ABCC3

Authors: K. Y. Lee, E. L. Beatson, M. A. Knechel, E. R. Sommer, G. C. Napoli, E. N. Risdon, A. F. Leon, R. D. Depaz, J. D. Strope, D. K. Price, C. H. Chau, W. D. Figg.

Journal: J Cancer. 2024 Jan 1;15(3):615-622.

Title: TGF-β and BMP signaling are associated with the transformation of glioblastoma to gliosarcoma and then osteosarcoma

Authors: A. Li, J. C. Hancock, M. Quezado, S. Ahn, N. Briceno, O. Celiku, S. Ranjan, O. Aboud, N. Colwell, S. A. Kim, E. Nduom, S. Kuhn, D. M. Park, E. Vera, K. Aldape, T. S. Armstrong, M. R. Gilbert.

Journal: Neurooncol Adv. 2023 Dec 19;6(1):vdad164.

Title: Decoding complexity in biomolecular recognition of DNA i-motifs with microarrays

Authors: Yazdani K, Seshadri S, Tillo D, Yang M, Sibley CD, Vinson C, Schneekloth.

Journal: Nucleic Acids Res. 2023 Dec 11;51(22):12020-12030.

Title: Cryptic splice mutation in the fumarate hydratase gene in patients with clinical manifestations of Hereditary Leiomyomatosis and Renal Cell Cancer

Authors: Crooks DR, Cawthon GM, Fitzsimmons CM, Perez M, Ricketts CJ, Vocke CD, Yang Y, Middelton L, Nielsen D, Schmidt LS, Tandon M, Merino MJ, Ball MW, Meier JL, Batista PJ, Linehan WM.

Journal: CHum Mol Genet. 2023 Nov 3;32(22):3135-3145.

Title: A novel GATA2 distal enhancer mutation results in MonoMAC syndrome in 2 second cousins

Authors: West RR, Bauer TR, Tuschong LM, Embree LJ, Calvo KR, Tillo D, Davis J, Holl, SM, Hickstein DD.

Journal: Blood Adv. 2023 Oct 24;7(20):6351-6363.

Title: PRDM10 RCC: A Birt-Hogg-Dubé-like Syndrome Associated With Lipoma and Highly Penetrant, Aggressive Renal Tumors Morphologically Resembling Type 2 Papillary Renal Cell Carcinoma

Authors: Schmidt LS, Vocke CD, Ricketts CJ, Blake Z, Choo KK, Nielsen D, Gautam R, Crooks DR, Reynolds KL, Krolus JL, Bashyal M, Karim B, Cowen EW, Malayeri AA, Merino MJ, Srinivasan R, Ball MW, Zbar B, Marston Linehan W.

Journal: Urology. 2023 Sep:179:58-70.

Title: Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin

Authors: Ruf, B., Bruhns, M., Babaei, S., Kedei, N., Ma, L., Revsine, M., Benmebarek, M. R., Ma, C., Heinrich, B., Subramanyam, V., Qi, J., Wabitsch, S., Green, B. L., Bauer, K. C., Myojin, Y., Greten, L. T., McCallen, J. D., Huang, P., Trehan, R., Wang, X., Greten, T. F.

Journal: Cell. 2023 Aug 17;186(17):3686-3705.e32.

Title: mRNA location and translation rate determine protein targeting to dual destinations

Authors: Gasparski AN, Moissoglu K, Pallikkuth S, Meydan S, Guydosh NR, Mili S.

Journal: Mol Cell. 2023 Aug 3;83(15):2726-2738.e9.

Title: Comprehensive mapping of cell fates in microsatellite unstable cancer cells support dual targe6ng of WRN and ATR

Authors: Zong D, Koussa NC, Cornwell JA, Pankajam AV, Kruhlak MJ, Wong N, Chari R, Cappell SD, Nussenzweig A.

Journal: bioRxiv[Preprint]. 2023 Jul 30:2023.07.28.550976.

Title: Efflux pump gene amplifications bypass necessity of multiple target mutations for resistance against dual-targeting antibiotic

Authors: Silva, K. P. T., Sundar, G., Khare, A.

Journal: Nat Commun. 2023 Jun 9;14(1):3402.

Title: High-throughput and targeted drug screens identify pharmacological candidates against MiT-translocation renal cell carcinoma

Authors: Lang M, Schmidt LS, Wilson KM, Ricketts CJ, Sourbier C, Vocke CD, Wei D, Crooks DR, Yang Y, Gibbs BK, Zhang X, Klumpp-Thomas C, Chen L, Guha R, Ferrer M, McKnight C, Itkin Z, Wangsa D, Wangsa D, James A, Difilippantonio S, Karim B, Morís F, Ried T, Merino MJ, Srinivasan R, Thomas CJ, Linehan WM.

Journal: J Exp Clin Cancer Res. 2023 Apr 25;42(1):99.

Title: Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and Is Associated with Worse Outcomes

Authors: Pongor, L. S., Schultz, C. W., Rinaldi, L., Wangsa, D., Redon, C. E., Takahashi, N., Fialkoff, G., Desai, P., Zhang, Y., Burkett, S., Hermoni, N., Vilk, N., Gutin, J., Rona, G., Zhao, Y., Nichols, S., Vilimas, R., Sciuto, L, Graham, C, Caravaca, J. M., Thomas, A.

Journal: Cancer Discov. 2023 Apr 3;13(4):928-949.

Title: A diagnosis of Birt-Hogg-Dubé syndrome in individuals with Smith-Magenis syndrome: Recommendation for cancer screening

Authors: vocke, C. D., Fleming, L. R., Piskorski, A. M., Amin, A., Phornphutkul, C., de la Monte, S., Vilboux, T., Duncan, F., Pellegrino, J., Braddock, B., Middelton, L. A., Schmidt, L. S., Merino, M. J., Cowen, E. W., Introne, W. J., Linehan, W. M., Smith, A. C. M.

Journal: Am J Med Genet A. 2023 Feb;191(2):490-497.

Title: Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis

Authors: Ghosal, S., Vanova, K. H., Uher, O., Das, S., Patel, M., Meuter, L., Huynh, T. T., Jha, A., Talvacchio, S., Knue, M., Prodanov, T., Zeiger, M. A., Nilubol, N., Taieb, D., Crona, J., Shankavaram, U. T., Pacak, K.

Journal: Endocrine. 2023 Jan;79(1):171-179.

Title: A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation

Authors: He, Y., Kim, I. K., Bian, J., Polyzos, A., Di Giammartino, D. C., Zhang, Y. W., Luo, J., Hernandez, M. O., Kedei, N., Cam, M., Borczuk, A. C., Lee, T., Han, Y., Conner, E. A., Wong, M., Tillo, D., C., Umemura, S., Chen, V., Ruan, L., White, J. B., Giaccone, G.

Journal: J Thorac Oncol. 2022 Dec;17(12):1375-1386.

Title: Context-Dependent Function of Long Noncoding RNA PURPL in Transcriptome Regulation during p53 Activation

Authors: Hartford, C. C. R., Shrestha, R. L., Pongor, L., Zhao, Y., Chen, X., Fromont, C., Chaudhary, R., Li, X. L., Pasterczyk, K. R., Kumar, R., Muys, B. R., Tsitsipatis, D., Chari, R., Gorospe, M., Aladjem, M. I., Khan, J., Basrai, M. A., Grammatikakis, I., Lal, A.

Journal: Mol Cell Biol. 2022 Dec 15;42(12):e0028922.

Title: Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

Authors: Palmer, D. C., Webber, B. R., Patel, Y., Johnson, M. J., Kariya, C. M., Lahr, W. S., Parkhurst, M. R., Gartner, J. J., Prickett, T. D., Lowery, F. J., Kishton, R. J., Gurusamy, D., Franco, Z., Vodnala, S. K., Diers, M. D., Wolf, N. K., Slipek, N. J., McKenna, D. H., Sumstad, D., Viney, L. Restifo, N. P.

Journal: Med. 2022 Oct 14;3(10):682-704.e8.

Title: Mutant Idh2 Cooperates with a NUP98-HOXD13 Fusion to Induce Early Immature Thymocyte Precursor ALL

Authors: Goldberg, L., Negi, V., Chung, Y. J., Onozawa, M., Zhu, Y. J., Walker, R. L., Pierce, R., Patel, D. P., Krausz, K. W., Gonzalez, F. J., Goodell, M. A., Rodriguez, B., Meltzer, P. S., Aplan, P. D.

Journal: Cancer Res. 2021 Oct 1;81(19):5033-5046.

Title: Mcm2 hypomorph leads to acute leukemia or hematopoietic stem cell failure, dependent on genetic context

Authors: Matsukawa, T., Yin, M., Baslan, T., Chung, Y. J., Cao, D., Bertoli, R., Zhu, Y. J., Walker, R. L., Freeland, A., Knudsen, E., Lowe, S. W., Meltzer, P. S., Aplan, P. D.

Journal: FASEB J. 2022 Sep;36(9):e22430.

Title: Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor

Authors: Zhang, X., Lou, H. E., Gopalan, V., Liu, Z., Jafarah, H. M., Lei, H., Jones, P., Sayers, C. M., Yohe, M. E., Chittiboina, P., Widemann, B. C., Thiele, C. J., Kelly, M. C., Hannenhalli, S., Shern, J. F.

Journal: Cell Rep. 2022 Sep 20;40(12):111363

Title: Anti-GD2 Antibodies Conjugated to IL15 and IL21 Mediate Potent Antitumor Cytotoxicity against Neuroblastoma

Authors: Nguyen, R., Zhang, X., Sun, M., Abbas, S., Seibert, C., Kelly, M. C., Shern, J. F., Thiele, C. J.

Journal: Clin Cancer Res. 2022 Sep 1;28(17):3785-3796.

Title: Differential VHL Mutation Patterns in Bilateral Clear Cell RCC Distinguishes Between Independent Primary Tumors and Contralateral Metastatic Disease

Authors: Vocke, C. D., Ricketts, C. J., Metwalli, A. R., Pinto, P. A., Gautam, R., Raffeld, M., Merino, M. J., Ball, M. W., Linehan, W. M.

Journal: Urology. 2022 Jul:165:170-177.

Title: Spatial meta-transcriptomics reveal associations of intratumor bacteria burden with lung cancer cells showing a distinct oncogenic signature

Authors: Wong-Rolle, A., Dong, Q., Zhu, Y., Divakar, P., Hor, J. L., Kedei, N., Wong, M., Tillo, D., Conner, E. A., Rajan, A., Schrump, D. S., Jin, C., Germain, R. N., Zhao, C.

Journal: J Immunother Cancer. 2022 Jul;10(7):e004698.

Title: OMA1 mediates local and global stress responses against protein misfolding in CHCHD10 mitochondrial myopathy

Authors: Shammas, M. K., Huang, X., Wu, B. P., Fessler, E., Song, I. Y., Randolph, N. P., Li, Y., Bleck, C. K., Springer, D. A., Fratter, C., Barbosa, I. A., Powers, A. F., Quirós, P. M., Lopez-Otin, C., Jae, L. T., Poulton, J., Narendra, D. P.

Journal: J Clin Invest. 2022 Jul 15;132(14):e157504.

Title: Systematic identification of molecular mediators of interspecies sensing in a community of two frequently coinfecting bacterial pathogens

Authors: Zarrella, T. M., Khare, A.

Journal: PLoS Biol. 2022 Jun 21;20(6):e3001679.

Title: NuRD complex recruitment to Thpok mediates CD4+ T cell lineage differentiation

Authors: Gao, Y., Zamisch, M., Vacchio, M., Chopp, L., Ciucci, T., Paine, E. L., Lyons, G. C., Nie, J., Xiao, Q., Zvezdova, E., Love, P. E., Vinson, C. R., Jenkins, L. M., Bosselut, R.

Journal: Sci Immunol. 2022 Jun 10;7(72):eabn5917.

Title: Convergence of SIRT1 and ATR signaling to modulate replication origin dormancy

Authors: Thakur, B. L., Baris, A. M., Fu, H., Redon, C. E., Pongor, L. S., Mosavarpour, S., Gross, J. M., Jang, S. M., Sebastian, R., Utani, K., Jenkins, L. M., Indig, F. E., Aladjem, M. I.

Journal: Nucleic Acids Res. 2022 May 20;50(9):5111-5128.

Title: The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8αα+ intraepithelial lymphocyte precursors

Authors: Nie, J., Carpenter, A. C., Chopp, L. B., Chen, T., Balmaceno-Criss, M., Ciucci, T., Xiao, Q., Kelly, M. C., McGavern, D. B., Belkaid, Y., Bosselut, R.

Journal: Nat Immunol. 2022 Apr;23(4):594-604.

Title: ASXL1 and STAG2 are common mutations in GATA2 deficiency patients with bone marrow disease and myelodysplastic syndrome

Authors: Robert R West, Katherine R Calvo, Lisa J Embree, Weixin Wang, Laura M Tuschong, Thomas R Bauer, Desiree Tillo, Justin Lack, Stephenie Droll, Amy P. Hsu, Steven M Holland, Dennis D Hickstein.

Journal: Blood Adv. 2022 Feb 8;6(3):793-807.

Title: A germline 1;3 translocation disrupting the VHL gene: a novel genetic cause for von Hippel-Lindau

Authors: Ricketts CJ, Vocke CD, Lang M, Chen X, Zhao Y, Tran B, Tandon M, Schmidt LS, Ball MW, Linehan WM.

Journal: J Med Genet. 2022 Jan;59(1):18-22.

Title: Dependence on Bcl6 and Blimp1 drive distinct differentiation of murine memory and follicular helper CD4+ T cells

Authors: Ciucci, T., Vacchio, M. S., Chen, T., Nie, J., Chopp, L. B., McGavern, D. B., Kelly, M. C., Bosselut, R.

Journal: J Exp Med. 2022 Jan 3;219(1):e20202343.

Title: Altering the Double-Stranded DNA Specificity of the bZIP Domain of Zta with Site-Directed Mutagenesis at N182

Authors: Ray S, Tillo D, Assad N, Ufot A, Porollo A, Durell SR, Vinson C.

Journal: ACS Omega. 2021 Dec 28;7(1):129-139.

Title: Nuclear pore protein NUP210 depletion suppresses metastasis through heterochromatin-mediated disruption of tumor cell mechanical response

Authors: Amin R, Shukla A, Zhu JJ, Kim S, Wang P, Tian SZ, Tran AD, Paul D, Cappell SD, Burkett S, Liu H.

Journal: Nat Commun. 2021 Dec 13;12(1):7216.

Title: Screening by deep sequencing reveals mediators of microRNA tailing in C. elegans

Authors: Vieux, K. F., Prothro, K. P., Kelley, L. H., Palmer, C., Maine, E. M., Veksler-Lublinsky, I., McJunkin, K.

Journal: Nucleic Acids Res. 2021 Nov 8;49(19):11167-11180.

Title: The intrinsic kinase activity of BRD4 spans its BD2-B-BID domains

Authors: Jocelyn D. Weissman, Amit K. Singh, Ballachanda N. Devaiah, Peter Schuck, Ross C. LaRue, Dinah S. Singer.

Journal: J Biol Chem. 2021 Nov;297(5):101326.

Title: Repeated strand invasion and extensive branch migration are hallmarks of meiotic recombination

Authors: Ahuja, J. S., Harvey, C. S., Wheeler, D. L., Lichten, M.

Journal: Mol Cell. 2021 Oct 21;81(20):4258-4270.e4.

Title: The ETS transcription factor ERF controls the exit from the naïve pluripotent state in a MAPK-dependent manner

Authors: Vega-Sendino M, Olbrich T, Tillo D, Tran AD, Domingo CM, Franco M, FitzGerald PC, Kruhlak MJ, Ruiz S.

Journal: Sci Adv. 2021 Oct;7(40):eabg8306.

Title: Structural basis for glucocorticoid receptor recognition of both unmodified and methylated binding sites, precursors of a modern recognition element

Authors: Liu X, Weikum ER, Tillo D, Vinson C, Ortlund EA.

Journal: Nucleic Acids Res. 2021 Sep 7;49(15):8923-8933.

Title: Improved systemic AAV gene therapy with a neurotrophic capsid in Niemann-Pick disease type C1 mice

Authors: Cristin D Davidson, Alana L Gibson, Tansy Gu, Laura L Baxter, Benjamin E Deverman, Keith Beadle, Arturo A Incao, Jorge L Rodriguez-Gil, Hideji Fujiwara, Xuntian Jiang, Randy J Chandler, Daniel S Ory, Viviana Gradinaru, Charles P Venditti, William J Pavan.

Journal: Life Sci Alliance. 2021 Aug 18;4(10):e202101040.

Title: CTCF is a barrier for 2C-like reprogramming

Authors: Olbrich T, Vega-Sendino M, Tillo D, Wu W, Zolnerowich N, Tran AD, Domingo CN, Franco M, Markiewicz-Potoczny M, Pegoraro G, FitzGerald PC, Kruhlak MJ, Lazzerini-Denchi E, Nora EP, Nussenzweig A, Ruiz S.

Journal: Nat Commun. 2021 Aug 11;12(1):4856.

Title: Direct identification of neoantigen-specific TCRs from tumor specimens by high-throughput single-cell sequencing

Authors: Lu Y, Zheng Z, Lowery FJ, et al.

Journal: J Immunother Cancer. 2021 Jul;9(7):e002595.

Title: Dynamics of replication origin over-activation

Authors: Fu, H., Redon, C.E., Thakur, B.L. et al.

Journal: Nat Commun. 2021 Jun 8;12(1):3448.

Title: Characterization of genetically defined sporadic and hereditary type 1 papillary renal cell carcinoma cell lines

Authors: Youfeng Yang, Christopher J Ricketts, Cathy D Vocke, J Keith Killian, Hesed M Padilla-Nash, Martin Lang, Darmood Wei, Young H Lee, Darawalee Wangsa, Carole Sourbier, Paul S Meltzer, Thomas Ried, Maria J Merino, Adam R Metwalli, Mark W Ball, Ramaprasad Srinivasan, W Marston Linehan.

Journal: Genes Chromosomes Cancer. 2021 Jun;60(6):434-446.

Title: Comprehensive characterization of Alu-mediated breakpoints in germline VHL gene deletions and rearrangements in patients from 71 VHL families

Authors: Vocke CD, Ricketts CJ, Schmidt LS, Ball MW, Middelton LA, Zbar B, Marston Linehan W.

Journal: Hum Mutat. 2021 May;42(5):520-529.

Title: Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

Authors: Kaczanowska, S., Beury, D. W., Gopalan, V., Tycko, A. K., Qin, H., Clements, M. E., Drake, J., Nwanze, C., Murgai, M., Rae, Z., Ju, W., Alexander, K. A., Kline, J., Contreras, C. F., Wessel, K. M., Patel, S., Hannenhalli, S., Kelly, M. C., Kaplan, R. N.

Journal: Cell. 2021 Apr 15;184(8):2033-2052.e21.

Title: Clinical and Molecular Characterization of Microphthalmia-associated Transcription Factor (MITF)-related Renal Cell Carcinoma

Authors: Martin Lang ,Cathy D. Vocke ,Christopher J. Ricketts ,Adam R. Metwalli , Mark W. Ball , Laura S. Schmidt , W. Marston Linehan.

Journal: Urology. 2021 Mar:149:89-97.

Title: EML4-ALK induces cellular senescence in mortal normal human cells and promotes anchorage-independent growth in hTERT-transduced normal human cells

Authors: Miyanaga A, Matsumoto M, Beck JA, Horikawa I, Oike T, Okayama H, Tanaka H, Burkett SS, Robles AI, Khan M, Lissa D, Seike M, Gemma A, Mano H, Harris CC.

Journal: BMC Cancer. 2021 Mar 24;21(1):310.

Title: Nascent RNA sequencing identifies a widespread sigma70-dependent pausing regulated by Gre factors in bacteria

Authors: Zhe Sun, Alexander V Yakhnin, Peter C FitzGerald, Carl E Mclntosh, Mikhail Kashlev.

Journal: Nat Commun. 2021 Feb 10;12(1):906.

Title: Somatic Mutations in UBA1 and Severe Adult-Onset Autoinflammatory Disease

Authors: Beck, David & Ferrada, Marcela & Sikora, KA & Ombrello, AK & Collins, JC & Pei, W & Balanda, N & Ross, DL & Cardona, D & Wu, Z & Patel, B & Manthiram, K & Groarke, EM & Gutierrez-Rodrigues, Fernanda & Hoffmann, P & Rosenzweig, S & Nakabo, Shuichiro & Dillon, LW & Hourigan, CS & Grayson, Peter.

Journal: N Engl J Med. 2020 Dec 31;383(27):2628-2638.

Title: Metastatic and recurrent adrenocortical cancer is not defined by its genomic landscape

Authors: Fojo, T., Huff, L., Litman, T. et al.

Journal: BMC Med Genomics. 2020 Nov 4;13(1):165.

Title: Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Authors: Niek van Wietmarschen et al.

Journal: Nature. 2020 Oct;586(7828):292-298.

Title: Novel renal medullary carcinoma cell lines, UOK353 and UOK360, provide preclinical tools to identify new therapeutic treatments

Authors: Wei D, Yang Y, Ricketts CJ, Vocke CD, Ball MW, Sourbier C, Wangsa D, Wangsa D, Guha R, Zhang X, Wilson K, Chen L, Meltzer PS, Ried T, Thomas CJ, Merino MJ, Linehan WM.

Journal: Genes Chromosomes Cancer. 2020 Aug;59(8):472-483.

Title: Custom G4 Microarrays Reveal Selective G-Quadruplex Recognition of Small Molecule BMVC: A Large-Scale Assessment of Ligand Binding Selectivity

Authors: Wu G, Tillo D, Ray S, Chang TC, Schneekloth JS Jr, Vinson C, Yang D.

Journal: Molecules. 2020 Jul 30;25(15):3465.

Title: Dissecting transcriptional amplification by MYC

Authors: Nie Z, Guo C, Das SK, et al.

Journal: Elife. 2020 Jul 27:9:e52483.

Title: Custom DNA Microarrays Reveal Diverse Binding Preferences of Proteins and Small Molecules to Thousands of G-Quadruplexes

Authors: Ray S, Tillo D, Boer RE, Assad N, Barshai M, Wu G, Orenstein Y, Yang D, Schneekloth JS Jr, Vinson C.

Journal: ACS Chem Biol. 2020 Apr 17;15(4):925-935.

Title: bZIP Dimers CREB1, ATF2, Zta, ATF3|cJun, and cFos|cJun Prefer to Bind to Some Double-Stranded DNA Sequences Containing 5-Formylcytosine and 5-Carboxylcytosine

Authors: Ray S, Tillo D, Ufot A, Assad N, Durell S, Vinson C.

Journal: Biochemistry. 2020 Sep 29;59(38):3529-3540.

Title: NusG controls transcription pausing and RNA polymerase translocation throughout the Bacillus subtilis genome

Authors: Alexander V Yakhnin, Peter C FitzGerald, Carl McIntosh, Helen Yakhnin, Maria Kireeva, Joshua Turek-Herman, Zachary F Mandell, Mikhail Kashlev, Paul Babitzke.

Journal: Proc Natl Acad Sci U S A. 2020 Sep 1;117(35):21628-21636.

Title: 53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination

Authors: Callen et al.

Journal: Mol Cell. 2020 Jan 2;77(1):26-38.e7.