This technology is provided in collaboration with CCR Spatial Imaging Technology Resource (SpITR). To get more information or to discuss a project, please contact Noemi Kedei, M.D., SpITR or Liz Conner, Ph.D. CCR Genomics Core.
Biomarker Discovery with Morphological Context
Changing how tissue specimens are analyzed
What is Digital Spatial Profiling?
GeoMx Digital Spatial Profiler is a novel platform developed by NanoString. Digital Spatial Profiling is based on nCounter® barcoding technology and enables spatially resolved, digital readout of up to 96 proteins or RNA targets in a multiplexed assay. The assay relies upon antibody or RNA probes coupled to photocleavable oligonucleotide tags. After hybridization of probes to slide-mounted formalin fixed paraffin-embedded (FFPE) tissue sections, the oligonucleotide tags are released from discrete regions of the tissue via UV exposure. Released tags are quantitated in a standard nCounter assay, and counts are mapped back to tissue location, yielding a spatially-resolved digital profile of analyte abundance.
